drug 肾上腺素的电子转移性质不仅与溶液的pH值有关,还与溶液的组成有关。同一pH值下不同缓冲溶液由于所含阴离子不同,对肾上腺素电子转移性质的影响也不同

:生物小分子与肾上腺素相互作用的伏安特性及理论研究

论文作者
论文导师 郁章玉,论文学位 硕士,论文专业 物理化学
论文单位 曲阜师范大学,点击次数 52,论文页数 111页File Size3768k
2006-04-01论文网 http://www.lw23.com/lunwen_76959807/
Small biological molecules;Adrenaline;Electron transfer;Hydrogen bonding complex;Cyclic voltammetry;Quantum chemistry
生物小分子是生物大分子的基本组成单元,也是生命活动的重要参与者。生物大分子活动的最终目标常常是化学小分子的代谢。肾上腺素是哺乳动物和人类的一种重要的儿茶酚胺类神经传递物质,它控制着神经系统进行一系列生物反应及神经化学过程。肾上腺素也是一种重要的生物分子。研究生物小分子与肾上腺素的相互作用,对于推动生命科学、药物化学、物理化学等学科的发展能起到一定的积极作用。本文用电化学方法和量子化学方法研究了生物小分子和肾上腺素的氢键作用。 本文选择生物小分子甘氨酸、甲酰胺、甲酸、乙酸、磷酸、硼酸等代表性的物质为研究对象,利用循环伏安法研究了它们在不同介质中对肾上腺素电子转移性质的影响。实验结果表明:生物小分子对肾上腺素具有一定的稳定作用,能在一定程度上抑制肾上腺素的氧化,从而改变了肾上腺素的循环伏安特征。 实验发现肾上腺素的电子转移性质不仅与溶液的pH值有关,还与溶液的组成有关。同一pH值下不同缓冲溶液由于所含阴离子不同,对肾上腺素电子转移性质的影响也不同。 甘氨酸、甲酰胺、甲酸、乙酸、磷酸、硼酸及相应酸根等能与肾上腺素形成氢键复合物。用量子化学方法优化了它们的几何构型,获得了结构参数和能量,解释了有关实验现象。
Small biological molecules are basic elements of large biological molecules, and also the important participants in the activities of life. The ultimate goal of the biological activity of large molecules are often metabolism of small chemical elements. Adrenaline is an important neurotransmitter of mammals and human beings, which controls both the nervous system to carry out a series of biological reactions and nerve chemical processes. Adrenaline is also a kind of biological molecules. To study the interaction between small biological molecules and adrenaline can propel the development of biology, pharmaceutical chemistry and physical chemistry, etc. In the present thesis, the interaction of hydrogen bond between adrenaline and small biological molecules has been investigated by means of electrochemistry and quantum chemistry.In this paper we choose some typical biological molecules to carry out the experiments,such as glycine, formamide, formic acid, ethanoic acid, phosphoric acid, boric acid and the corresponding acid groups. Cyclic voltammetry was performed to study the effect of small biological molecules on the cyclic voltammetric properties of adrenaline in different mediums. The results indicate that small biological molecules have stabilization on adrenaline, so that the ability of oxidation of adrenaline decreases, which alters the cyclic voltammetric properties of adrenaline.The results show that the electron-transfer nature of adrenaline is related not only to the pH value of the solution,also to the composition of it. Different buffer solutions with the same pH value have different influence on adrenaline"s electron-transfer because they contain different anions.The hydrogen bonding complexes can be formed between small biologicalmolecules and adrenaline. The quantum studies are carried out in this thesis. The geometries of adrenaline and the stable complexes are respectively optimized to obtain structural parameters and binding energies. The calculation results can be better used to explain some experimental phenomena